USMLE Step 2 Clinical Knowledge (CK): the practice module
Exam body: FSMB and NBME. Verified for USMLE Content Outline (2026) and Step 2 CK test specifications on October 16, 2026.
What it covers
Covers: standard multiple-choice questions written to this exam’s outline, format and timing.
Does not cover: sequential item set, abstract format, image-based, audio or video, long-list (7 or more options). DoMcq is multiple-choice only; the real exam’s other item types are out of scope.
Question format
- Each question has between 4 and 6 options.
- One correct answer per question.
- Not allowed as an option: “all of the above”, “none of the above”.
- Stems follow the exam’s conventions, such as “Which of the following is the most appropriate next step in management?”, “Which of the following is the most likely diagnosis?”, “Which of the following is the most appropriate next step in diagnosis?”.
Exam mode
The real exam is 316 questions in 480 minutes. Exam mode keeps that pace for any number of questions.
Topics
The official topic list, as the exam body names it. Your questions must use these names; the coverage dashboard compares your set to each topic’s official weight.
| Topic | Weight | Subtopics |
|---|---|---|
| Social Sciences | 10–15% | Patient Care: Diagnosis · Patient Care: Laboratory/Diagnostic Studies · Patient Care: Mixed Management · Patient Care: Pharmacotherapy · Patient Care: Clinical Interventions · Patient Care: Health Maintenance/Disease Prevention · Patient Care: Prognosis/Outcome · Systems-based Practice & Patient Safety · Professionalism · Practice-based Learning & Improvement |
| Renal & Urinary System & Reproductive Systems | 7–13% | Patient Care: Diagnosis · Patient Care: Laboratory/Diagnostic Studies · Patient Care: Mixed Management · Patient Care: Pharmacotherapy · Patient Care: Clinical Interventions · Patient Care: Health Maintenance/Disease Prevention · Patient Care: Prognosis/Outcome · Systems-based Practice & Patient Safety · Professionalism · Practice-based Learning & Improvement |
| Cardiovascular System | 6–12% | Patient Care: Diagnosis · Patient Care: Laboratory/Diagnostic Studies · Patient Care: Mixed Management · Patient Care: Pharmacotherapy · Patient Care: Clinical Interventions · Patient Care: Health Maintenance/Disease Prevention · Patient Care: Prognosis/Outcome · Systems-based Practice & Patient Safety · Professionalism · Practice-based Learning & Improvement |
| Musculoskeletal System/Skin & Subcutaneous Tissue | 6–12% | Patient Care: Diagnosis · Patient Care: Laboratory/Diagnostic Studies · Patient Care: Mixed Management · Patient Care: Pharmacotherapy · Patient Care: Clinical Interventions · Patient Care: Health Maintenance/Disease Prevention · Patient Care: Prognosis/Outcome · Systems-based Practice & Patient Safety · Professionalism · Practice-based Learning & Improvement |
| Behavioral Health | 5–10% | Patient Care: Diagnosis · Patient Care: Laboratory/Diagnostic Studies · Patient Care: Mixed Management · Patient Care: Pharmacotherapy · Patient Care: Clinical Interventions · Patient Care: Health Maintenance/Disease Prevention · Patient Care: Prognosis/Outcome · Systems-based Practice & Patient Safety · Professionalism · Practice-based Learning & Improvement |
| Blood & Lymphoreticular/Immune Systems | 5–10% | Patient Care: Diagnosis · Patient Care: Laboratory/Diagnostic Studies · Patient Care: Mixed Management · Patient Care: Pharmacotherapy · Patient Care: Clinical Interventions · Patient Care: Health Maintenance/Disease Prevention · Patient Care: Prognosis/Outcome · Systems-based Practice & Patient Safety · Professionalism · Practice-based Learning & Improvement |
| Gastrointestinal System | 5–10% | Patient Care: Diagnosis · Patient Care: Laboratory/Diagnostic Studies · Patient Care: Mixed Management · Patient Care: Pharmacotherapy · Patient Care: Clinical Interventions · Patient Care: Health Maintenance/Disease Prevention · Patient Care: Prognosis/Outcome · Systems-based Practice & Patient Safety · Professionalism · Practice-based Learning & Improvement |
| Nervous System & Special Senses | 5–10% | Patient Care: Diagnosis · Patient Care: Laboratory/Diagnostic Studies · Patient Care: Mixed Management · Patient Care: Pharmacotherapy · Patient Care: Clinical Interventions · Patient Care: Health Maintenance/Disease Prevention · Patient Care: Prognosis/Outcome · Systems-based Practice & Patient Safety · Professionalism · Practice-based Learning & Improvement |
| Respiratory System | 5–10% | Patient Care: Diagnosis · Patient Care: Laboratory/Diagnostic Studies · Patient Care: Mixed Management · Patient Care: Pharmacotherapy · Patient Care: Clinical Interventions · Patient Care: Health Maintenance/Disease Prevention · Patient Care: Prognosis/Outcome · Systems-based Practice & Patient Safety · Professionalism · Practice-based Learning & Improvement |
| Multisystem Processes & Disorders | 4–8% | Patient Care: Diagnosis · Patient Care: Laboratory/Diagnostic Studies · Patient Care: Mixed Management · Patient Care: Pharmacotherapy · Patient Care: Clinical Interventions · Patient Care: Health Maintenance/Disease Prevention · Patient Care: Prognosis/Outcome · Systems-based Practice & Patient Safety · Professionalism · Practice-based Learning & Improvement |
| Endocrine System | 3–7% | Patient Care: Diagnosis · Patient Care: Laboratory/Diagnostic Studies · Patient Care: Mixed Management · Patient Care: Pharmacotherapy · Patient Care: Clinical Interventions · Patient Care: Health Maintenance/Disease Prevention · Patient Care: Prognosis/Outcome · Systems-based Practice & Patient Safety · Professionalism · Practice-based Learning & Improvement |
| Pregnancy, Childbirth & the Puerperium | 3–7% | Patient Care: Diagnosis · Patient Care: Laboratory/Diagnostic Studies · Patient Care: Mixed Management · Patient Care: Pharmacotherapy · Patient Care: Clinical Interventions · Patient Care: Health Maintenance/Disease Prevention · Patient Care: Prognosis/Outcome · Systems-based Practice & Patient Safety · Professionalism · Practice-based Learning & Improvement |
| Biostatistics & Epidemiology/Population Health/Medical Literature | 3–5% | Patient Care: Diagnosis · Patient Care: Laboratory/Diagnostic Studies · Patient Care: Mixed Management · Patient Care: Pharmacotherapy · Patient Care: Clinical Interventions · Patient Care: Health Maintenance/Disease Prevention · Patient Care: Prognosis/Outcome · Systems-based Practice & Patient Safety · Professionalism · Practice-based Learning & Improvement |
| Human Development | 2–4% | Patient Care: Diagnosis · Patient Care: Laboratory/Diagnostic Studies · Patient Care: Mixed Management · Patient Care: Pharmacotherapy · Patient Care: Clinical Interventions · Patient Care: Health Maintenance/Disease Prevention · Patient Care: Prognosis/Outcome · Systems-based Practice & Patient Safety · Professionalism · Practice-based Learning & Improvement |
Trademarks
DoMcq is an independent practice tool and is not affiliated with, sponsored by or endorsed by the USMLE program, the Federation of State Medical Boards (FSMB) or the National Board of Medical Examiners (NBME); the names are used only to identify the exam. The United States Medical Licensing Examination® (USMLE®) is a joint program of the FSMB and NBME; USMLE® and NBME® are registered trademarks of their owners.
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