USMLE Step 1: the practice module

Exam body: FSMB and NBME. Verified for USMLE Content Outline (2026) and Step 1 test specifications on October 16, 2026.

What it covers

Covers: standard multiple-choice questions written to this exam’s outline, format and timing.

Does not cover: image-based, audio, long-list (7 or more options). DoMcq is multiple-choice only; the real exam’s other item types are out of scope.

Question format

  • Each question has between 4 and 6 options.
  • One correct answer per question.
  • Not allowed as an option: “all of the above”, “none of the above”.
  • Stems follow the exam’s conventions, such as “Which of the following is the most likely diagnosis?”, “Which of the following is the most likely underlying cause of this patient's condition?”, “Which of the following is the most appropriate initial response by the physician?”, “Which of the following infectious agents is the most likely cause of these findings?”.

Exam mode

The real exam is 280 questions in 420 minutes. Exam mode keeps that pace for any number of questions.

Topics

The official topic list, as the exam body names it. Your questions must use these names; the coverage dashboard compares your set to each topic’s official weight.

TopicWeightSubtopics
Human Development1–3%Pathology · Physiology · Nutrition · Gross Anatomy & Embryology · Microbiology · Pharmacology · Behavioral Sciences · Biochemistry · Histology & Cell Biology · Immunology · Genetics
Blood & Lymphoreticular/Immune Systems9–13%Pathology · Physiology · Nutrition · Gross Anatomy & Embryology · Microbiology · Pharmacology · Behavioral Sciences · Biochemistry · Histology & Cell Biology · Immunology · Genetics
Behavioral Health & Nervous Systems/Special Senses10–14%Pathology · Physiology · Nutrition · Gross Anatomy & Embryology · Microbiology · Pharmacology · Behavioral Sciences · Biochemistry · Histology & Cell Biology · Immunology · Genetics
Musculoskeletal, Skin & Subcutaneous Tissue8–12%Pathology · Physiology · Nutrition · Gross Anatomy & Embryology · Microbiology · Pharmacology · Behavioral Sciences · Biochemistry · Histology & Cell Biology · Immunology · Genetics
Cardiovascular System7–11%Pathology · Physiology · Nutrition · Gross Anatomy & Embryology · Microbiology · Pharmacology · Behavioral Sciences · Biochemistry · Histology & Cell Biology · Immunology · Genetics
Respiratory & Renal/Urinary Systems11–15%Pathology · Physiology · Nutrition · Gross Anatomy & Embryology · Microbiology · Pharmacology · Behavioral Sciences · Biochemistry · Histology & Cell Biology · Immunology · Genetics
Gastrointestinal System6–10%Pathology · Physiology · Nutrition · Gross Anatomy & Embryology · Microbiology · Pharmacology · Behavioral Sciences · Biochemistry · Histology & Cell Biology · Immunology · Genetics
Reproductive & Endocrine Systems12–16%Pathology · Physiology · Nutrition · Gross Anatomy & Embryology · Microbiology · Pharmacology · Behavioral Sciences · Biochemistry · Histology & Cell Biology · Immunology · Genetics
Multisystem Processes & Disorders8–12%Pathology · Physiology · Nutrition · Gross Anatomy & Embryology · Microbiology · Pharmacology · Behavioral Sciences · Biochemistry · Histology & Cell Biology · Immunology · Genetics
Biostatistics & Epidemiology/Population Health4–6%Pathology · Physiology · Nutrition · Gross Anatomy & Embryology · Microbiology · Pharmacology · Behavioral Sciences · Biochemistry · Histology & Cell Biology · Immunology · Genetics
Social Sciences: Communication and Interpersonal Skills6–9%Pathology · Physiology · Nutrition · Gross Anatomy & Embryology · Microbiology · Pharmacology · Behavioral Sciences · Biochemistry · Histology & Cell Biology · Immunology · Genetics

Trademarks

DoMcq is an independent practice tool and is not affiliated with, sponsored by or endorsed by the USMLE program, the Federation of State Medical Boards (FSMB) or the National Board of Medical Examiners (NBME); the names are used only to identify the exam. The United States Medical Licensing Examination® (USMLE®) is a joint program of the FSMB and NBME; USMLE® and NBME® are registered trademarks of their owners.

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