USMLE Step 1: the practice module
Exam body: FSMB and NBME. Verified for USMLE Content Outline (2026) and Step 1 test specifications on October 16, 2026.
What it covers
Covers: standard multiple-choice questions written to this exam’s outline, format and timing.
Does not cover: image-based, audio, long-list (7 or more options). DoMcq is multiple-choice only; the real exam’s other item types are out of scope.
Question format
- Each question has between 4 and 6 options.
- One correct answer per question.
- Not allowed as an option: “all of the above”, “none of the above”.
- Stems follow the exam’s conventions, such as “Which of the following is the most likely diagnosis?”, “Which of the following is the most likely underlying cause of this patient's condition?”, “Which of the following is the most appropriate initial response by the physician?”, “Which of the following infectious agents is the most likely cause of these findings?”.
Exam mode
The real exam is 280 questions in 420 minutes. Exam mode keeps that pace for any number of questions.
Topics
The official topic list, as the exam body names it. Your questions must use these names; the coverage dashboard compares your set to each topic’s official weight.
| Topic | Weight | Subtopics |
|---|---|---|
| Human Development | 1–3% | Pathology · Physiology · Nutrition · Gross Anatomy & Embryology · Microbiology · Pharmacology · Behavioral Sciences · Biochemistry · Histology & Cell Biology · Immunology · Genetics |
| Blood & Lymphoreticular/Immune Systems | 9–13% | Pathology · Physiology · Nutrition · Gross Anatomy & Embryology · Microbiology · Pharmacology · Behavioral Sciences · Biochemistry · Histology & Cell Biology · Immunology · Genetics |
| Behavioral Health & Nervous Systems/Special Senses | 10–14% | Pathology · Physiology · Nutrition · Gross Anatomy & Embryology · Microbiology · Pharmacology · Behavioral Sciences · Biochemistry · Histology & Cell Biology · Immunology · Genetics |
| Musculoskeletal, Skin & Subcutaneous Tissue | 8–12% | Pathology · Physiology · Nutrition · Gross Anatomy & Embryology · Microbiology · Pharmacology · Behavioral Sciences · Biochemistry · Histology & Cell Biology · Immunology · Genetics |
| Cardiovascular System | 7–11% | Pathology · Physiology · Nutrition · Gross Anatomy & Embryology · Microbiology · Pharmacology · Behavioral Sciences · Biochemistry · Histology & Cell Biology · Immunology · Genetics |
| Respiratory & Renal/Urinary Systems | 11–15% | Pathology · Physiology · Nutrition · Gross Anatomy & Embryology · Microbiology · Pharmacology · Behavioral Sciences · Biochemistry · Histology & Cell Biology · Immunology · Genetics |
| Gastrointestinal System | 6–10% | Pathology · Physiology · Nutrition · Gross Anatomy & Embryology · Microbiology · Pharmacology · Behavioral Sciences · Biochemistry · Histology & Cell Biology · Immunology · Genetics |
| Reproductive & Endocrine Systems | 12–16% | Pathology · Physiology · Nutrition · Gross Anatomy & Embryology · Microbiology · Pharmacology · Behavioral Sciences · Biochemistry · Histology & Cell Biology · Immunology · Genetics |
| Multisystem Processes & Disorders | 8–12% | Pathology · Physiology · Nutrition · Gross Anatomy & Embryology · Microbiology · Pharmacology · Behavioral Sciences · Biochemistry · Histology & Cell Biology · Immunology · Genetics |
| Biostatistics & Epidemiology/Population Health | 4–6% | Pathology · Physiology · Nutrition · Gross Anatomy & Embryology · Microbiology · Pharmacology · Behavioral Sciences · Biochemistry · Histology & Cell Biology · Immunology · Genetics |
| Social Sciences: Communication and Interpersonal Skills | 6–9% | Pathology · Physiology · Nutrition · Gross Anatomy & Embryology · Microbiology · Pharmacology · Behavioral Sciences · Biochemistry · Histology & Cell Biology · Immunology · Genetics |
Trademarks
DoMcq is an independent practice tool and is not affiliated with, sponsored by or endorsed by the USMLE program, the Federation of State Medical Boards (FSMB) or the National Board of Medical Examiners (NBME); the names are used only to identify the exam. The United States Medical Licensing Examination® (USMLE®) is a joint program of the FSMB and NBME; USMLE® and NBME® are registered trademarks of their owners.
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